Shandong University team has made new progress in the field of diabetic nephropathy and autophagy regulation

2022-05-23 0 By

Recently, Professor Ma Chunhong, School of Basic Medical Sciences, and Professor Yang Xiangdong, Qilu Hospital published a paper in the journal of Redox Biology.IF=11.799) published “Upregulation of TIPE1 in diabetic cell aggravates diabetic nephropathy by disrupting PHB2Mediated mitophagy “.Liu Lei, PhD candidate from the College of Clinical Medicine, was the first author, and Professor Liang Xiaohong from Shandong University and Professor Yang Xiangdong from the Department of Nephrology of Qilu Hospital were the co-corresponding authors. Shandong University was the first and only corresponding author.According to the World Diabetes Association, the incidence of diabetes is increasing year by year, and there will be about 592 million diabetics by 2035.Diabetic nephropathy is one of the important complications of diabetes mellitus, and the pathogenesis is complex, among which the damage and fibrosis of renal tubular epithelial cells are the main reasons leading to the decline of renal function.In this study, we demonstrated for the first time that the expression of tumor necrosis factor α -induced protein 8-molecule-1 (TIPE1) increased under high glucose stimulation and resulted in impaired mitochondrial function of renal tubular epithelial cells, thereby promoting the progression of diabetic nephropathy.In this study, we found that TIPE1 can bind PHB2 to promote ubiquitination and degradation of PHB2 through the proteasome pathway, and down-regulate PHB2 expression, resulting in decreased mitochondrial autophagy activity and impaired function, and promoting the progression of diabetic nephropathy.Meanwhile, this study confirmed that TIPE1 expression was significantly correlated with renal fibrosis and renal function using clinical specimens, which may provide a new target for the treatment of diabetic nephropathy in the future.Prof. Chunhong Ma’s team and Prof. Xiangdong Yang’s team are mainly engaged in the research of immune microenvironment and metabolic diseases. The previous collaborative study found that the immunomodulatory molecule Tim3 activates the NF-κB signaling pathway in macrophages and exacerbates the progression of diabetic nephropathy.Related research results have been published in J Exp Med, GUT, Cell Mol Immunol, J HEPATOL, CANCER RES, Molecular Metabolism, Cell Death andDifferentiation and other important international journals.The above research was supported by the key projects of the National Natural Science Foundation of China, the General projects of the National Natural Science Foundation of China and the National Key RESEARCH and Development Program.The original link: https://doi.org/10.1016/j.redox.2022.102260 source: shandong university